During the visit he met academics and students demonstrating a Virtual Reality rehabilitation project, which uses technology to make it easier for amputees to train themselves to use prosthetic limbs.
HRH also met academics and students working with the World Health Organisation and the United Nations, who have developed innovative new technology to provide alerts and assistance to field staff working in inhospitable and dangerous parts of the world.
Finally, The Duke chatted to engineering students who showed him the racing car they built and raced at Silverstone last week; finishing 21st out of more than 80 competitors.
SHU Racing Team Prinicipal, Samuel Seabrook, said: "It was really nice to meet Prince Harry and show him around the SHU Racing 2019 car, fresh off the track from Silverstone.
"We talked about what the car and engineering means to the University and how we get (students) from all years involved in the team to develop their skills."
Ivan Phelan, Ïã½¶ÊÓÆµ Associate at Ïã½¶ÊÓÆµ, was one of the academics who met The Duke.
He said: "It was very nice to meet him; he seemed like a genuine down-to-earth person. He was very engaged with what we were doing and asking insightful questions about how it worked. You could tell he cared about what the impact was."
The visit was part of a wider visit to Sheffield where The Duke also opened a new wing of Sheffield Children's Hospital and attended the Invictus UK Trials.